Osiris is an old Warlock who was exiled from The City, due to his obsession with the Vex and the Infinite Forest, and was said to have "come too close" to understanding the Vex. He has knowledge about the inner working of the Hive, as he knew about the Shrine of Oryx.
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The Guardian is summoned by Ikora Rey, who shows him Sagira, Osiris's Ghost, and shares a report that Vex activity has surged dramatically. The Guardian goes to Mercury, where a member of the cult of Osiris, Brother Vance, awaits their arrival. Unfortunately, they were unable to enter the gateway that led to the Infinite Forest. They then go to Earth to activate Sagira at an Osiris base, but the brothers there were killed by Fallen before they arrived. Luckily, the ghost shell is revived when the Guardian gets close to a certain book. Somehow, Sagira is then merged with the Guardian's Ghost, taking control of him. The player soon returns to Mercury, where they are now able to pass through the gateway to the Infinite Forest.
- There are three known members of the Cult of Osiris who still live: Osiris himself, Brother Vance, and Sister Faora.
- Osiris was Ikora Rey's mentor.
- Osiris is the only Vanguard Commander to have been exiled, and has been referred to as "the Zavala before Zavala".
- In Season of the Dawn, Osiris becomes something like a vendor.
- (2017) YouTube: Destiny 2 - Expansion I: Curse of Osiris Reveal Trailer 1:44. Retrieved November 1, 2017.
- Bungie (2014) Destiny, Shrine of Oryx. Activision.
- Tread of the Hezen Lords
- (2015) GameInformer: 104 Questions And Answers About Destiny: The Taken King 1:25. Retrieved August 24, 2015.
- List of Grimoire Cards/Disciples of Osiris